| Identification | Back Directory | [Name]
Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- | [CAS]
341001-38-5 | [Synonyms]
CS-681
Nucleozin
Nucleozin >=98% (HPLC), powder
1-(2-Chloro-4-nitrophenyl)-4-[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]-piperazine
[4-(2-Chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)methanone
Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-
[4-(2-Chloro-4-nitro-phenyl)-piperazin-1-yl]-(5-methyl-3-phenyl-isoxazol-4-yl)-methanone | [Molecular Formula]
C21H19ClN4O4 | [MDL Number]
MFCD01426660 | [MOL File]
341001-38-5.mol | [Molecular Weight]
426.85 |
| Hazard Information | Back Directory | [Uses]
Nucleozin may be used in anti-viral (anti-influenza) research to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an influenza A nucleoprotein (a multifunctional, RNA-binding protein necessary for virus replication) targeting drug candidate. | [Biological Activity]
Nucleozin targets influenza A nucleoprotein (NP)a multifunctionalRNA-binding protein necessary for virus replication. Nucleozin is effective in fighting H1N1H3N2and H5N1 flu virus strains by inducing the formation of NP aggregates and antagonizing its nuclear accumulationleading to cessation of viral replication.''Nucleozin targets influenza A nucleoproteina multifunctionalRNA-binding protein necessary for virus replication. It induces the formation of nucleoptotein aggregates and inhibits its accumulationinterfering with viral replication. EC50 is in the nM range. Nucleozin is effective in H1N1H3N2and H5N1 flu virus strains. | [target]
Influenza Virus NP |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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