| Identification | Back Directory | [Name]
BIS(4-HYDROXYCINNAMOYL)METHANE | [CAS]
33171-05-0 | [Synonyms]
CURCUMIN 3
Didemethoxycurcumin
BISDEMETHOXY CURCUMIN
BIS-DESMETHOXYCURCUMIN
DEMETHOXYCURCUMIN, BIS-
Bisdemethoxycurcumin(b)
(E,E)-BisdeMethoxycurcuMin
Bisdemethoxycurcumin(BDMC)
BIS(4-HYDROXYCINNAMOYL)METHANE
Bis(p-hydroxycinnamoyl)methane
PARAPARADIHYDROXYDICINNAMOYLMETHANE
BIS(4-HYDROXYCINNAMOYL)METHANE USP/EP/BP
(E,E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
(1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
Bisdemethoxycurcumin, 98%, from Zingiber officinale Rosc.
1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (E,E)-
1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (1E,6E)-
Deleted CAS No: 22608-12-4, 85801-92-9, 91884-88-7, 104024-29-5 | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C19H16O4 | [MDL Number]
MFCD03419284 | [MOL File]
33171-05-0.mol | [Molecular Weight]
308.33 |
| Chemical Properties | Back Directory | [Melting point ]
221-223 ºC | [Boiling point ]
551.3±45.0 °C(Predicted) | [density ]
1.285 | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
solid | [pka]
8.50±0.46(Predicted) | [color ]
Orange to Dark Orange | [BRN ]
3149384 | [Stability:]
Light Sensitive | [LogP]
3.155 (est) |
| Hazard Information | Back Directory | [Uses]
Bisdemethoxycurcumin is one of the three major forms of curcuminoids found in the rhizomes of turmeric. Bisdemethoxycurcumin displays antioxidant, anti-inflammatory as well as chemotherapeutic activit
y. Bisdemethoxycurcumin acts as an inhibitor of human pancreatic α-amylase, a target for type-2 diabetes . | [Definition]
ChEBI: Bisdemethoxycurcumin is a beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups. It has a role as a metabolite and an EC 3.2.1.1 (alpha-amylase) inhibitor. It is a beta-diketone, a polyphenol, an enone and a diarylheptanoid. It is functionally related to a 4-coumaric acid. | [General Description]
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | [Biochem/physiol Actions]
Bisdemethoxycurcumin (BDMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. BDMC shares similar anti-inflammatory properties with demethoxycurcumin. It inhibits LPS-induced nitric oxide (NO) production and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. BDMC also displays unique properties in that it enhances Abeta clearance by upregulating expression MGAT3 and TLR genes. BDMC potently inhibits AKR1B10. |
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