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ChemicalBook--->CAS DataBase List--->284040-76-2

284040-76-2

284040-76-2 Structure

284040-76-2 Structure
IdentificationBack Directory
[Name]

AC9-25
[CAS]

284040-76-2
[Synonyms]

AC9-25
[Molecular Formula]

C13H15N3O3.C3H9N
[MDL Number]

MFCD01692079
[MOL File]

284040-76-2.mol
[Molecular Weight]

320.391
Chemical PropertiesBack Directory
[Boiling point ]

2439.8±65.0 °C(Predicted)
[density ]

1.354±0.06 g/cm3(Predicted)
[storage temp. ]

Desiccate at -20°C
[form ]

Solid
[pka]

3.29±0.10(Predicted)
[color ]

White to off-white
[Water Solubility ]

Soluble to 1 mg/ml in 20% acetonitrile / Water
Hazard InformationBack Directory
[Uses]

Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR[1][2].
[References]

[1] Walther A, et al. A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell. 2000;5(5):831-840. DOI:10.1016/s1097-2765(00)80323-8
[2] Karlsson J, et al. Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J Leukoc Biol. 2005;78(3):762-771. DOI:10.1189/jlb.0305153
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40963-14-2 81334-34-1

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