| Identification | Back Directory | [Name]
6-FLUOROMEVALONATE | [CAS]
2822-77-7 | [Synonyms]
6-fluoromevalonolactone
6-Fluoromevalonate >=90% (GC), viscous liquid
2H-Pyran-2-one, 4-(fluoromethyl)tetrahydro-4-hydroxy-
Tetrahydro-4-fluoromethyl-4-hydroxy-2H-pyran-2-one, ZR 3516 | [Molecular Formula]
C6H9FO3 | [MDL Number]
MFCD08276919 | [MOL File]
2822-77-7.mol | [Molecular Weight]
148.13 |
| Chemical Properties | Back Directory | [Boiling point ]
307.8±22.0 °C(Predicted) | [density ]
1.277±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥3 mg/mL | [form ]
viscous liquid | [pka]
12.25±0.20(Predicted) | [color ]
yellow tint |
| Hazard Information | Back Directory | [Uses]
6-Fluoromevalonate has been used as a mevalonate pyrophosphate decarboxylase inhibitor:
- to study the effect of mevalonate pathway inhibition on patient-derived brain tumor-initiating cells (BTICs) growth and self-renewal
- to study its effect on induction of trained immunity by β-glucan in monocytes
- to determine the effect of the mevalonate pathway (MVP) on ADP-ribosylation factor 6 (ARF6) activation
| [Definition]
ChEBI: 4-(fluoromethyl)-4-hydroxy-2-oxanone is a delta-lactone. | [Biological Activity]
Mevalonate-pyrophosphate decarboxylase inhibitor |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
SIGMA-RBI
|
| Tel: |
800 736 3690 (Orders) |
| Website: |
www.sigma-aldrich.com |
|