| Identification | Back Directory | [Name]
1H-Imidazole-1-ethanol, 2-(ethoxymethyl)-4-iodo-α,α-dimethyl-5-phenyl- | [CAS]
2573912-32-8 | [Synonyms]
CU-CPD107
1H-Imidazole-1-ethanol, 2-(ethoxymethyl)-4-iodo-α,α-dimethyl-5-phenyl- | [Molecular Formula]
C16H21IN2O2 | [MOL File]
2573912-32-8.mol | [Molecular Weight]
400.26 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 80 mg/mL (199.87 mM);Ethanol: 80 mg/mL (199.87 mM) | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Biological Activity]
CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. In the presence of R848, CU-CPD107 acts as a TLR8 signaling inhibitor (IC50=13.7 μM). In the presence of ssRNA, CU-CPD107 shows synergistic agonist activities, while CU-CPD107 alone is unable to influence TLR8 signaling.
CU-CPD107, a tetrasubstituted imidazole, inhibits R848-induced TLR8 signaling and shows unexpected synergistic agonist activities in the presence of ssRNA, while CU-CPD107 alone is unable to influence TLR8 signaling.[1] | [References]
[1] Yang Y, et al. Nat Commun. 2021 Jul 16;12(1):4351. |
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| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
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http://www.yuhua99.com/ShowSupplierProductsList927327/0.htm |
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