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ChemicalBook--->CAS DataBase List--->251647-55-9

251647-55-9

251647-55-9 Structure

251647-55-9 Structure
IdentificationBack Directory
[Name]

DMT-2μ-O-Me-rG(ib) amidite
[CAS]

251647-55-9
[Synonyms]

DMT-2'-O-MOE-G(iBu)-CEP
DMT-2μ-O-Me-rG(ib) amidite
2'-O-MOE-ibu-G Phosphoramidite
2'-MOE-G(iBu)-3'-phosphoramidite
2'-O-MOE-rG(ibu) Phosphoramidite
2'-O-MOE-G(iBu)-CE Phosphoramidite
DMT-2'-O-MOE-G(iBu)-CE-Phosphoramidite
5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine 3'-CE phosphoramidite
5'-O-DMT-N2-isobutyryl-2'-O-?methoxyethylguanosine 3'-CE phosphoramidite
N2-isobutyryl-5'-O-DMT-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-O- methoxyethyl-guanosine-3'-cyanoethyl Phosphoramidite
5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-methylguanosine-3'-(2-cyanoethyl diisopropylphosphoramidite)
5’-O-(4,4’-Dimethoxy-trityl)-N2-iso-butyroyl-2’-O-(2-methoxyethyl)guanosine-3’-O-[(2-cyanoethyl)(N,N-diisopropyl)]-phosphoramidite
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
Guanosine, 5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-(2-Methoxyethyl)-N-(2-Methyl-1-oxopropyl)-, 3'-[2-cyanoethyl bis(1-Methylethyl)phosphoraMidite]
Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
GUANOSINE, 5'-O-[BIS(4-METHOXYPHENYL)PHENYLMETHYL]-2'-O-(2-METHOXYETHYL)-N-(2-METHYL-1-OXOPROPYL)-, 3'-[2-CYANOETHYL BIS(1-METHYLETHYL)PHOSPHORAMIDITE] (9CI)
[Molecular Formula]

C47H60N7O10P
[MDL Number]

MFCD00792625
[MOL File]

251647-55-9.mol
[Molecular Weight]

913.99
Chemical PropertiesBack Directory
[storage temp. ]

4°C, protect from light
[solubility ]

DMSO : 250 mg/mL (273.53 mM; Need ultrasonic)
[form ]

Powder
[pka]

9.16±0.20(Predicted)
[color ]

White to Off-white
[InChIKey]

LADCDGNEBIQAAU-KEFUZROQNA-N
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319
[Precautionary statements ]

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard InformationBack Directory
[Description]

Nucleoside phosphoramidites are used in the synthesis of oligonucleotides. Using a chemical approach allows quick and inexpensive access to custom-made oligonucleotides of the desired sequence. Enzymatic synthesis proceeds in a 5’ to 3’ direction, however the chemical synthesis is usually performed in the opposite direction. 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite, also known as DMT-2μ-O-Me-rG(ib) amidite, is a modified guanosine with a 2’-O-(2-methoxyethyl) group, these have been used in the synthesis of oligonucleotides as antisense drugs.
[Uses]

5''-O-DMT-N2-isobutyryl-2''-O-(2-methoxyethyl)-guanosine 3''-CE phosphoramidite (CAS# 251647-55-9) is a nucleotide, and a derivative of guanosine, and is used in the stereochemical sythesis of phosphorothioate oligonucleotides.
[storage]

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
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