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ChemicalBook--->CAS DataBase List--->2502156-03-6

2502156-03-6

2502156-03-6 Structure

2502156-03-6 Structure
IdentificationBack Directory
[Name]

PROTAC KRASG12C Degrader-LC-2
[CAS]

2502156-03-6
[Synonyms]

LC-2
PROTAC KRASG12C Degrader-LC-2
[Molecular Formula]

C59H71ClFN11O7S
[MDL Number]

MFCD32857122
[Molecular Weight]

1132.78
Chemical PropertiesBack Directory
[density ]

1.297±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 50 mg/mL (44.14 mM; ultrasonic and warming and heat to 80°C)
[form ]

Solid
[pka]

14.07±0.40(Predicted)
[color ]

Off-white to brown
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Description]

LC-2 is a von Hippel-Lindau-based PROTAC which can degrade endogenous KRAS G12C. It covalently binds KRAS G12C with a MARTX849 warhead and recruits the E3 ligase VHL which degrades the KRAS G12C and suppresses MAPK signaling in homozygous and heterzygous KRAS G12C cell lines.
[storage]

Store at -20°C
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