| Identification | Back Directory | [Name]
Benzenepropanamide, N-(3-chloro-4-methylphenyl)-3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]- | [CAS]
2438124-79-7 | [Synonyms]
Benzenepropanamide, N-(3-chloro-4-methylphenyl)-3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]- | [Molecular Formula]
C25H23ClN4O5 | [MOL File]
2438124-79-7.mol | [Molecular Weight]
494.93 |
| Chemical Properties | Back Directory | [Boiling point ]
778.9±60.0 °C(Predicted) | [density ]
1.470±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (101.02 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.69±0.40(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Biological Activity]
ALV1 is a potent Ikaros and Helios degrader. ALV1 potently reduces the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal protein RPL4. ALV1 shows similar degradation activity towards IKZF1/2/3. ALV1 induced Helios/CRBN dimerization. ALV1 promoted IL-2 secretion to a great extent[1]. | [storage]
Store at -20°C | [References]
[1]. Wang ES, et al. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 2021 Jun;17(6):711-717. |
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