| Identification | Back Directory | [Name]
Spiro[1H-furo[3,4-c]pyrrole-1,2'-[2H]indene]-1',3',4,6(3H,5H)-tetrone, 5'-bromo-5-(2-chlorophenyl)-3a,6a-dihydro-3-(4-methylphenyl)-, (3S,3aR,6aS)- | [CAS]
2414908-52-2 | [Synonyms]
Adenylyl cyclase type 2 agonist-1
Spiro[1H-furo[3,4-c]pyrrole-1,2'-[2H]indene]-1',3',4,6(3H,5H)-tetrone, 5'-bromo-5-(2-chlorophenyl)-3a,6a-dihydro-3-(4-methylphenyl)-, (3S,3aR,6aS)- | [Molecular Formula]
C27H17BrClNO5 | [MOL File]
2414908-52-2.mol | [Molecular Weight]
550.79 |
| Chemical Properties | Back Directory | [Boiling point ]
797.3±60.0 °C(Predicted) | [density ]
1.69±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-1.78±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Adenylyl cyclase type 2 agonist-1 (Compound 73) is a potent agonist of adenylyl cyclase type 2 (AC2) with the EC50 of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases[1]. | [References]
[1] Guowei Xu, et al. The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation. Eur J Med Chem. 2020 Apr 1;191:112115. DOI:10.1016/j.ejmech.2020.112115 |
|
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
www.biorbyt.com |
|