| Identification | Back Directory | [Name]
cRIPGBM | [CAS]
2361988-77-2 | [Synonyms]
cRIPGBM(chloride)
1-Benzyl-3-(4-fluorobenzyl)-2-methyl-4,9-dioxo-4,9- dihydro-1H-naphtho[2,3-d]imidazol-3-ium chloride | [Molecular Formula]
C26H20ClFN2O2 | [MDL Number]
MFCD34596421 | [MOL File]
2361988-77-2.mol | [Molecular Weight]
446.91 |
| Hazard Information | Back Directory | [Biological Activity]
cRIPGBM is an apoptosis inducer (GBM-1/-5/-39 EC50 = 63/95/290 nM; human neural progenitor cells (NPCs)/astrocytes/lung fibroblasts EC50 = 190/710/960 nM) th at binds receptor-interacting protein kinase 2 (RIPK2RIP2) and promotes the formation of a proapoptotic RIPK2/caspase-1 complex. Cell type-selective metabolic redox conversion of RIPGBM to cRIPGBM in glioblastoma multiforme (GBM) cancer stem cells (CSCs) form the basis of selective GBM CSCs apoptosis induction by RIPGBM over non-GBM cultures. |
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