| Identification | Back Directory | [Name]
Spastazoline | [CAS]
2351882-11-4 | [Synonyms]
Spastazoline
(R)-N-(5-(tert-Butyl)-1H-pyrazol-3-yl)-2-(3-isopropylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[5-(1,1-dimethylethyl)-1H-pyrazol-3-yl]-2-[(3R)-3-(1-methylethyl)-1-piperazinyl]- | [Molecular Formula]
C20H30N8 | [MDL Number]
MFCD31813810 | [MOL File]
2351882-11-4.mol | [Molecular Weight]
382.51 |
| Chemical Properties | Back Directory | [density ]
1.222±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (261.43 mM; Need ultrasonic) | [form ]
Solid | [pka]
14.26±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
Spastazoline is a selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC50 of 99 nM for Human spastin. Spastazoline can be used for cell division- and intracellular vesicle transport-related research[1]. | [Biological Activity]
Spastazoline is a cell penetrantpotent and selective ATP-competitive inhibitor of spastin. | [References]
[1] Cupido T, et al. Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Nat Chem Biol. 2019 Feb 18. DOI:10.1038/s41589-019-0225-6 |
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