| Identification | Back Directory | [Name]
9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester | [CAS]
2256087-35-9 | [Synonyms]
9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester | [Molecular Formula]
C59H113NO5 | [MOL File]
2256087-35-9.mol | [Molecular Weight]
916.53 |
| Chemical Properties | Back Directory | [Boiling point ]
854.2±65.0 °C(Predicted) | [density ]
0.915±0.06 g/cm3(Predicted) | [solubility ]
DMSO: soluble | [form ]
Viscous Liquid | [pka]
15.21±0.29(Predicted) |
| Hazard Information | Back Directory | [Description]
CL4H6 is an ionizable cationic amino lipid (apparent pKa = 6.35) that has been used in the generation of lipid nanoparticles (LNPs).1 LNPs containing CL4H6 and encapsulating Factor VII-targeting siRNA decrease hepatic levels of Factor VII in mice. Intravenous administration of LNPs containing CL4H6 and encapsulating siRNA targeting CD45 accumulate in tumor-associated macrophages and encapsulating siRNAs targeting STAT3 and HIF-1α decrease tumor volume in OS-RC-2 renal cancer mouse xenograft models.2 | [References]
1. Sato, Y., Hashiba, K., Sasaki, K., et al. Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo J. Control. Release 295,140-152(2019).
2. Shobaki, N., Sato, Y., Suzuki, Y., et al. Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy J. Control. Release 325,235-248(2020). |
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DC Chemicals
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InvivoChem
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