| Identification | Back Directory | [Name]
CAY10735 | [CAS]
2251753-58-7 | [Synonyms]
CAY10735
Olean-12-en-28-amide, N-[2-[[[1-[[(4-fluorophenyl)amino]carbonyl]cyclopropyl]carbonyl]amino]ethyl]-2-methylene-3-oxo- | [Molecular Formula]
C44H60FN3O4 | [MOL File]
2251753-58-7.mol | [Molecular Weight]
713.96 |
| Hazard Information | Back Directory | [Description]
CAY10735 is an anticancer compound that inhibits proliferation of melanoma, breast, pancreatic, and lung cancer cell lines by inhibiting the epithelial-to-mesenchymal transition (EMT). | [Uses]
Anti-CSCs agent-1 is a potent anti-CSCs agent. Anti-CSCs agent-1 inhibits cell growth and cell migration. Anti-CSCs agent-1 induces Apoptosis. Anti-CSCs agent-1 inhibits the viability of CSCs. Anti-CSCs agent-1 enhances the production of ROS in CSCs. Anti-CSCs agent-1 shows antitumor activity[1]. | [in vivo]
Anti-CSCs agent-1 (5 mg/kg; i.p.; daily for 15 days) shows antitumor activity in mouse[1]. | Animal Model: | C57BL/6J mice (A375 cells)[1] | | Dosage: | 5 mg/kg | | Administration: | I.p.; daily for 15 days | | Result: | Significantly inhibited tumor growth. |
| [storage]
Store at -20°C | [References]
[1] Liu X, et al. Synthesis and Discovery Novel Anti-Cancer Stem Cells Compounds Derived from the Natural Triterpenoic Acids. J Med Chem. 2018 Dec 13;61(23):10814-10833. DOI:10.1021/acs.jmedchem.8b01445 |
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