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ChemicalBook--->CAS DataBase List--->2237925-62-9

2237925-62-9

2237925-62-9 Structure

2237925-62-9 Structure
IdentificationBack Directory
[Name]

2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-5-(dimethylamino)-6-(2-phenylethynyl)-, hydrochloride (1:1)
[CAS]

2237925-62-9
[Synonyms]

DMA-135
DMA-135 hydrochloride
2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-5-(dimethylamino)-6-(2-phenylethynyl)-, hydrochloride (1:1)
[Molecular Formula]

C16H18ClN7O
[MOL File]

2237925-62-9.mol
[Molecular Weight]

359.82
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[form ]

Solid
[color ]

Light yellow to yellow
[Water Solubility ]

H2O: 2mg/mL, clear
Hazard InformationBack Directory
[Biological Activity]

DMA-135 is a cell penetrant and potent inhibitor of human enterovirus 71 (EV71) translation and replication th at targets the IRES domain of EV71. DMA-135 binds allosterically to EV71 SLII RNA and stabilizes ternary complex consisting of AUF1-SLII-DMA-135. Alsoprevious data indicate th at DMA-135 exhibit comparable affinity to HIV-1-TAR and HIV-2-TAR.
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