| Identification | Back Directory | [Name]
1400 W DIHYDROCHLORIDE, 96 | [CAS]
214358-33-5 | [Synonyms]
1400W2HCl
1400W (hydrochloride)
1400 W DIHYDROCHLORIDE, 96
N-(3-(aMinoMethyl)benzyl)acetiMidaMide dihydrochloride
N-[3-(AMinoMethyl)benzyl]ethaniMidaMide dihydrochloride | [Molecular Formula]
C8H11NO | [MDL Number]
MFCD03428622 | [MOL File]
214358-33-5.mol | [Molecular Weight]
137.179 |
| Chemical Properties | Back Directory | [Appearance]
white to off-white powder | [Melting point ]
208 °C | [storage temp. ]
−20°C | [solubility ]
Soluble in Water (up to 25 mg/ml). | [form ]
White solid | [color ]
White | [Water Solubility ]
Soluble to 100 mM in water | [Stability:]
Stable for 1 year as supplied. Solutions are not stable. Solutions must be prepared fresh and used within one working day. |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white powder | [Uses]
A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM. | [Description]
1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3?(Ki?= 7 nM) over nNOS or eNOS (Ki‘s of 2 μM and 50 μM respectively).1?1400W is cell permeable and active?in vivo.2 | [General Description]
A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS. | [Biochem/physiol Actions]
Cell permeable: yes | [storage]
Desiccate at RT | [References]
References/Citations
1) Garvey?et al. (1997),?1400W is a slow, tight-binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo; J. Biol. Chem.,?272?4959
2) Thomsen?et al. (1997),?Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor; Cancer Res.,?57?3300
3) Pigott?et al. (2013),?On the selectivity of neuronal NOS inhibitors; Br. J. Pharmacol.,?168?1255 |
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| Company Name: |
Synchem OHG
|
| Tel: |
+49 5662 408730 |
| Website: |
www.synchem.de |
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