| Identification | Back Directory | [Name]
SW203668 (trifluoroacetate salt) | [CAS]
2117405-48-6 | [Synonyms]
SW203668 (trifluoroacetate salt)
SW203668 (trifluoroacetate salt),SW-203668 (trifluoroacetate salt) | [Molecular Formula]
C24H20F3N3O4S | [MDL Number]
MFCD30480921 | [MOL File]
2117405-48-6.mol | [Molecular Weight]
503.5 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/mL; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and nonobese diabetic severe combined immunodeficiency (NOD-SCID) mouse xenograft models when administered at doses of 20 and 6 mg/kg, respectively. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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