| Identification | Back Directory | [Name]
1H-Cyclopenta[d][1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide, N-[2,5-dimethyl-4-[[1-oxo-3-(5-phenyl-1,3,4-oxadiazol-2-yl)propyl]amino]phenyl]-5,6,7,8-tetrahydro-8-oxo- | [CAS]
2083618-79-3 | [Synonyms]
PDZ1i
1H-Cyclopenta[d][1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide, N-[2,5-dimethyl-4-[[1-oxo-3-(5-phenyl-1,3,4-oxadiazol-2-yl)propyl]amino]phenyl]-5,6,7,8-tetrahydro-8-oxo- | [Molecular Formula]
C28H26N8O4 | [MOL File]
2083618-79-3.mol | [Molecular Weight]
538.56 |
| Hazard Information | Back Directory | [Description]
PDZ1i, also known as 113B7, is an inhibitor of MDA-9/Syntenin activity. PDZ1i radiosensitized GBM cells. PDZ1i inhibited crucial GBM signaling involving FAK and mutant EGFR, EGFRvIII, and abrogated gains in secreted proteases, MMP-2 and MMP-9, following radiation. In an in vivo glioma model, PDZ1i resulted in smaller, less invasive tumors and enhanced survival. When combined with radiation, survival gains exceeded radiotherapy alone. |
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| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
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http://www.yuhua99.com/ShowSupplierProductsList927327/0.htm |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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www.biorbyt.com |
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