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ChemicalBook--->CAS DataBase List--->2070009-66-2

2070009-66-2

2070009-66-2 Structure

2070009-66-2 Structure
IdentificationBack Directory
[Name]

A-674563 (hydrochloride)
[CAS]

2070009-66-2
[Synonyms]

A-674563 (hydrochloride)
A-674563 hydrochloride (A 674563 hydrochloride
[Molecular Formula]

C??H??ClN?O
[MDL Number]

MFCD18711680
[MOL File]

2070009-66-2.mol
[Molecular Weight]

394.9
Chemical PropertiesBack Directory
[storage temp. ]

-10 to -25°C
[form ]

Solid
[color ]

Light yellow to khaki
[Water Solubility ]

H2O: 2mg/mL, clear
Hazard InformationBack Directory
[Uses]

A-674563 Hydrochloride is a potent, orally available Akt1 inhibitor.
[Biological Activity]

A-674563 is an orally available ATP-competitive pan-AKT (PKBprotein Kinase B) inhibitor (AKT1 Ki = 11 nM) with additional potency against PKACdk2 GSK3β (IC50 = 1.44.2,10 nMrespectively). A-674563 reduces the phosphorylation of cellular Akt substrates (0.1-10 μM; MiaPaCa-2) and enhances paclitaxel efficacy in a PC-3 xenograft model in mice in vivo (40 mg A-674563/kg via p.o. b.i.d. for 21 days15 mg paclitaxel/day on days 202428).
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