| Chemical Properties | Back Directory | [Boiling point ]
529.3±50.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
15.22±0.60(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. It displays 14-fold selectivity for GSK3β. BRD3731 displays reduced potency towards the GSK3β (D133E), with an IC50 = 53 nM compared to GSK3β (wt) (cf. IC50 = 15 nM). Moreover, BRD3731 inhibits GSK3β with a Kd of 3.3 μM in cellular context. In addition, BRD3731 is a GSK3β- selective inhibitor from patent US20160375006A1, compound example 272. |
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