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ChemicalBook--->CAS DataBase List--->18471-20-0

18471-20-0

18471-20-0 Structure

18471-20-0 Structure
IdentificationBack Directory
[Name]

ditazole
[CAS]

18471-20-0
[Synonyms]

S-222
ditazol
Apt-574
ditazole
Agerophas
Diethamphenazole
2,2'-[(4,5-Diphenyl-2-oxazolyl)imino]bisethanol
2-[(4,5-diphenyl-1,3-oxazol-2-yl)-(2-hydroxyethyl)amino]ethanol
[EINECS(EC#)]

242-353-5
[Molecular Formula]

C19H20N2O3
[MDL Number]

MFCD00866073
[MOL File]

18471-20-0.mol
[Molecular Weight]

324.37
Chemical PropertiesBack Directory
[Melting point ]

100-101°C
[storage temp. ]

Refrigerator
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

Solid
[color ]

White to Off-White
Hazard InformationBack Directory
[Originator]

Ageroplas,Serona,Italy,1973
[Uses]

Ditazole is a weak anti-inflammatory drug and a novel inhibitor of platelet aggregation.
[Definition]

ChEBI: Ditazole is a member of 1,3-oxazoles.
[Manufacturing Process]

A solution of 5.1 grams 2-chloro-4,5-diphenyl-oxazole, 6.3 grams diethanolamine and 50 ml absolute ethanol was refluxed for 4 hours. The solvent was stripped at 1 mm and the oily residue was added at 60°C to 100 ml 50% ethanol; by cooling the hydro-alcoholic solution, 4.5 grams of 2-bis(β- hydroxyethyl)amino-4,5-diphenyl-oxazole was obtained (yield, 69.5%). The product crystallized from ethyl ether + petroleum ether, with a MP of 96 to 98°C.
[Therapeutic Function]

Antiinflammatory
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Tags:18471-20-0 Related Product Information
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