| Identification | Back Directory | [Name]
Propargyl-PEG2-methylamine | [CAS]
1835759-76-6 | [Synonyms]
Propargyl-PEG2-NHMe
Propargyl-PEG2-methylamine
Ethanamine, N-methyl-2-[2-(2-propyn-1-yloxy)ethoxy]- | [Molecular Formula]
C8H15NO2 | [MOL File]
1835759-76-6.mol | [Molecular Weight]
157.21 |
| Chemical Properties | Back Directory | [Boiling point ]
214.6±20.0 °C(Predicted) | [density ]
0.947±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
9.50±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG2-methylamine is a crosslinker with a propargyl group and methylamine group. The propargyl group forms triazole linkage with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. | [Uses]
Propargyl-PEG2-methylamine (Propargyl-PEG2-NHMe) is a PEG derivative containing a propargyl group and methylamine group. Propargyl-PEG2-methylamine is an PROTAC linker used in the synthesis of PROTACs. Propargyl-PEG2-methylamine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1]. | [References]
[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781 |
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