| Identification | Back Directory | [Name]
Ribocil-C | [CAS]
1825355-56-3 | [Synonyms]
Ribocil-C
4(3H)-Pyrimidinone, 2-[(3S)-1-[[1-(2-pyrimidinyl)-1H-imidazol-4-yl]methyl]-3-piperidinyl]-6-(2-thienyl)- | [Molecular Formula]
C21H21N7OS | [MOL File]
1825355-56-3.mol | [Molecular Weight]
419.5 |
| Chemical Properties | Back Directory | [Boiling point ]
672.0±65.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 24.6 mg/mL (58.64 mM) | [form ]
Solid | [pka]
8.44±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
Ribocil-C is a potent inhibitor of bacterial riboflavin riboswitches. Riboswitches are cis regulatory elements present in non-coding RNA th at specifically bind to natural ligands to regulate gene expression. Ribocil-C blocks the flavin mononucleotide riboswitch-mediated expression of the ribB genewhich is required for riboflavin biosynthesiswith an IC50 value of 23 nM. Ribocil-C inhibited bacterial cell growth of E. coli MB5746 and bacterial burden in a mouse E. coli septicaemia model of infection. |
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