| Identification | Back Directory | [Name]
TD52 | [CAS]
1798328-24-1 | [Synonyms]
TD52
TD52 >=98% (HPLC)
2,3-Quinoxalinediamine, N2,N3-bis(3-ethynylphenyl)-
breast,triple-negative,TD52,inhibit,HCC-1937,orally,Erlotinib,TD 52,CIP2A,Protein kinase B,p-Akt,p-EGFR,Apoptosis,PKB,Elk1,PP2A,Inhibitor,TD-52,cancer,Phosphatase,TNBC,Akt | [Molecular Formula]
C24H16N4 | [MDL Number]
MFCD31697737 | [MOL File]
1798328-24-1.mol | [Molecular Weight]
360.41 |
| Chemical Properties | Back Directory | [Boiling point ]
530.0±50.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 5 mg/ml | [form ]
A solid | [pka]
2.45±0.59(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Biological Activity]
TD52an erlotinib analogis a putative inhibitor of CIP2A th at exhibits potent antitumor efficacy on HCC and TNBC cells. TD52 induces apoptosis through downregulation of CIP2A (Cancerous inhibitor of protein phosphatase 2A) in HCCNSCLC and TNBC cells. Apparently TD52 indirectly downregulates CIP2A transcripts through interrupting the binding of Elk1 to CIP2A promoter. TD52 is a weak inhibitor of EGFR tyrosine kinase. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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