| Identification | Back Directory | [Name]
methyl 3-(4-methylphenylsulfonamido)benzoate | [CAS]
173436-66-3 | [Synonyms]
MSAB
GSK549
MSAB >=95% (HPLC)
methyl 3-(4-methylphenylsulfonamido)benzoate
Methyl 3-(4-Methylbenzenesulfonamido)benzoate
Benzoic acid, 3-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester | [Molecular Formula]
C15H15NO4S | [MDL Number]
MFCD00994918 | [MOL File]
173436-66-3.mol | [Molecular Weight]
305.35 |
| Chemical Properties | Back Directory | [Melting point ]
152-154 °C | [Boiling point ]
456.5±55.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly) | [form ]
powder | [pka]
7.88±0.10(Predicted) | [color ]
off-white to purple |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth. |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
| Company Name: |
Twochem Co.Ltd
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021-021-58111628 15800915896 |
| Website: |
www.twochem.com |
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