| Identification | Back Directory | [Name]
GR 205171 | [CAS]
168266-90-8 | [Synonyms]
GR 205171
Vofopitant
Vofopitant (GR 205171)
3-Piperidinamine, N-[[2-methoxy-5-[5-(trifluormethyl)-1H-tetrazol-1-yl]phenyl]methyl]-2-phenyl, (2S,3S)
3-Piperidinamine, N-[[2-methoxy-5-[5-(trifluormethyl)-1H-tetrazol-1-yl]phenyl]methyl]-2-phenyl, (2S-cis-) | [Molecular Formula]
C21H23F3N6O
| [MOL File]
168266-90-8.mol | [Molecular Weight]
432.44 |
| Chemical Properties | Back Directory | [Appearance]
Yellowish solid | [Boiling point ]
542.5±60.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.13±0.10(Predicted) | [color ]
Light yellow to yellow | [CAS DataBase Reference]
168266-90-8 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellowish solid | [Uses]
rac-Vofopitant-d3 (rac-GR 205171-d3) is the deuterium labeled Vofopitant (HY-12142)[1]. Vofopitant is potent tachykinin NK1 receptor antagonist, with pKis of 10.6, 9.5, and 9.8 for human, rat and ferret NK1 receptor, respectively[2]. | [storage]
Store at -20°C | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110 |
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