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ChemicalBook--->CAS DataBase List--->1609937-15-6

1609937-15-6

1609937-15-6 Structure

1609937-15-6 Structure
IdentificationBack Directory
[Name]

Mambalgin 1
[CAS]

1609937-15-6
[Synonyms]

Mambalgin 1
Mambalgin 1 USP/EP/BP
[Molecular Formula]

C272H429N85O84S9
[MOL File]

1609937-15-6.mol
[Molecular Weight]

6522.42
Hazard InformationBack Directory
[Uses]

Mambalgin-1 is a toxin isolated from black mamba venom. Mambalgin-1 is a disulfide-rich polypeptide consisting of 57 amino acids and belongs to the family of three-finger toxins. Mambalgin-1 can bind to and stabilize ASICs (acid-sensing ion channels) in a physiologically relevant closed-channel conformation[1].
[References]

[1] Sun D, et al. Cryo-EM structure of the ASIC1a-mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect. Cell Discov. 2018;4:27. Published 2018 Jun 5. DOI:10.1038/s41421-018-0026-1
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