| Identification | Back Directory | [Name]
FMoc-Val-Cit-PAB | [CAS]
159858-22-7 | [Synonyms]
FMoc-Val-Cit-PAB
Fmoc-Val-Cit-PAB-OH
Fmoc-val-citrulline-para-aminobenzyl-OH
L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
(9H-fluoren-9-yl)methyl ((2S)-1-((1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
(9H-fluoren-9-yl)methyl((S)-1-((())-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
(9H-fluoren-9-yl)methyl N-[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(hydroxymethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylpropyl]carbamate
(9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate | [Molecular Formula]
C33H39N5O6 | [MDL Number]
MFCD22417106 | [MOL File]
159858-22-7.mol | [Molecular Weight]
601.69 |
| Chemical Properties | Back Directory | [Melting point ]
204 °C(dec.) | [Boiling point ]
914.2±65.0 °C(Predicted) | [density ]
1.276±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [form ]
powder to crystal | [pka]
10.63±0.46(Predicted) | [color ]
White to Almost white | [CAS DataBase Reference]
159858-22-7 |
| Hazard Information | Back Directory | [Description]
Fmoc-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Fmoc can be deprotected under basic condition. |
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