| Identification | Back Directory | [Name]
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methoxypropanoic acid | [CAS]
1569103-64-5 | [Synonyms]
N-Fmoc-N,O-dimethyl-L-serine
L-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N,O-dimethyl-
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-methoxypropanoic acid
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methoxypropanoic acid | [Molecular Formula]
C20H21NO5 | [MOL File]
1569103-64-5.mol | [Molecular Weight]
355.38 |
| Chemical Properties | Back Directory | [Boiling point ]
540.6±50.0 °C(Predicted) | [density ]
1.266±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.42±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
N-Fmoc-N,O-dimethyl-L-serine is a serine derivative that can be used for coibamide A synthesis. Coibamide A is a marine natural product with potent antiproliferative activity against human cancer cells[1][2]. | [References]
[1] Yao G, et al. Efficient Synthesis and Stereochemical Revision of Coibamide A. J Am Chem Soc. 2015 Oct 28;137(42):13488-91. DOI:10.1021/jacs.5b09286
[2] Tranter D, et al. Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins. ACS Chem Biol. 2020 Aug 21;15(8):2125-2136. DOI:10.1021/acschembio.0c00325 |
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