| Identification | Back Directory | [Name]
Dofequidar fuMarate | [CAS]
153653-30-6 | [Synonyms]
Dofequidar (2E)-2-butenedioate (1:1) | [Molecular Formula]
C34H35N3O7 | [MDL Number]
MFCD00925095 | [MOL File]
153653-30-6.mol | [Molecular Weight]
597.658 |
| Hazard Information | Back Directory | [Biological Activity]
dofequidar fumarate is a multidrug-resistant (mdr) - reversal agent [1].dofequidar fumarate is a quinoline derivative and has highly potent reversing effect on multidrug-resistant tumor cells. it prevents the transport of antitumor drugs through interacting with the drug-efflux pump p-glycoprotein directly and thereby reverses mdr. in vincristine (vcr)-resistant p388/vcr cells and adriamycin (adm)- resistant p388/adm cells, dofequidar fumarate at 1μm and 3μm can completely reverse the drug resistance. it also shows significant effects on the mdr k562 cells. furthermore, in mice model bearing hct-15 xenografts, combination therapy of dofequidar fumarate and docetaxel induces remarkable tumor growth inhibition. dofequidar fumarate also shows significant reversing effect in mcf-7/adm-bearing mice [1, 2]. | [References]
[1] sato w, fukazawa n, nakanishi o, et al. reversal of multidrug resistance by a novel quinoline derivative, ms-209. cancer chemotherapy and pharmacology, 1995, 35(4): 271-277.
[2] naito m, matsuba y, sato s, et al. ms-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models. clinical cancer research, 2002, 8(2): 582-588. |
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SPIRO PHARMA
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www.spiropharma.com.cn |
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Musechem
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www.musechem.com |
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DC Chemicals
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