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ChemicalBook--->CAS DataBase List--->152658-36-1

152658-36-1

152658-36-1 Structure

152658-36-1 Structure
IdentificationBack Directory
[Name]

(E)-N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
[CAS]

152658-36-1
[Synonyms]

Emorfazone Impurity 8
Nalfuranfine Impurity 9
2-Propenamide, N-[(5α,6α)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-, (2E)-
(E)-N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
[Molecular Formula]

C28H32N2O5
[MOL File]

152658-36-1.mol
[Molecular Weight]

476.57
Chemical PropertiesBack Directory
[Boiling point ]

700.7±60.0 °C(Predicted)
[density ]

1.41±0.1 g/cm3(Predicted)
[pka]

9.37±0.60(Predicted)
Hazard InformationBack Directory
[Uses]

6S-Nalfurafine-d3 is the labeled analogue of 6S-Nalfurafine (N255615), a stereoisomer of Nalfurafine (N255600), a on-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test. Nalfurafine is a new therapeutic agent for the treatment of uremic pruritus in hemodialysis patients.
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