| Identification | Back Directory | [Name]
Alverine | [CAS]
150-59-4 | [Synonyms]
SESTRON
PROFENIL
ALVERINE
dipropylin
DIPROPYLINE
Seston base
sestronbase
Alverine base
phenpropamine
PHENOPROPAMINE
Alverine (free base)
di(phenylpropyl)ethylamine
BIS(GAMMA-PHENYLPROPYL)ETHYLAMINE
n-ethyl-3,3’-diphenyl-dipropylamin
n-ethyl-3,3’-diphenyldipropylamine
N-Ethyl-3,3'-diphenyldipropylamine
n-ethyl-n-(3-phenylpropyl)benzenepropanamine
n-ethyl-n-(3-phenylpropyl)-benzenepropanamin
Benzenepropanamine, N-ethyl-N-(3-phenylpropyl)-
N-Ethyl-N-(3-phenylpropyl)benzenepropan-1-amine
N-Ethyl-3-phenyl-N-(3-phenylpropyl)-1-propanamine
Bis(gamma-phenylpropyl)ethylamine
Dipropyline
Phenopropamine
Profenil
Sestron | [EINECS(EC#)]
205-763-5 | [Molecular Formula]
C20H27N | [MDL Number]
MFCD00075035 | [MOL File]
150-59-4.mol | [Molecular Weight]
281.44 |
| Hazard Information | Back Directory | [Definition]
ChEBI: A tertiary amine having one ethyl and two 3-phenylprop-1-yl groups attached to the nitrogen. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used (particularly as the citrate salt) in the treatment of irritable bowel synd
ome. | [Originator]
Alverine citrate,Kemikos | [Uses]
Anticholinergic. | [Manufacturing Process]
2 Methods of producing of alverine:
1. 3-Phenylpropylchloride reacted with ethylamine in the presence potassium
hydroxide and N-ethyl-3,3'-diphenyldipropylamine (alverine) was obtained.
2. 3-Phenylpropenal reacted with ethylamine in the presence hydrogen and Pt
as catalyst and BaSO4 and N-ethyl-3,3'-diphenyldipropylamine (alverine) was
obtained.
In practice it is usually used as citrate. | [Therapeutic Function]
Anticholinergic, Spasmolytic |
| Safety Data | Back Directory | [Hazardous Substances Data]
150-59-4(Hazardous Substances Data) | [Toxicity]
women,TDLo,oral,126mg/kg/5W-I (126mg/kg),BEHAVIORAL: ANOREXIA (HUMANLIVER: LIVER FUNCTION TESTS IMPAIREDLIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE",Journal of Hepathology. Vol. 27, Pg. 399, 1997. |
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