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ChemicalBook--->CAS DataBase List--->149759-26-2

149759-26-2

149759-26-2 Structure

149759-26-2 Structure
IdentificationBack Directory
[Name]

LOE 908 HYDROCHLORIDE
[CAS]

149759-26-2
[Synonyms]

LOE 908
Pinokalant
LOE 908 HYDROCHLORIDE
1-Isoquinolineacetamide, 3,4-dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-
3,4-Dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-1-isoquinolineacetamidehydrochloride
[Molecular Formula]

C41H48N2O9
[MDL Number]

MFCD09038554
[MOL File]

149759-26-2.mol
[Molecular Weight]

712.83
Chemical PropertiesBack Directory
[Boiling point ]

803.7±65.0 °C(Predicted)
[density ]

1.17±0.1 g/cm3(Predicted)
[storage temp. ]

Desiccate at RT
[pka]

5.47±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

LOE 908 Hydrochloride is a isoquinoline derivative and a cation channel blocker. LOE 908 Hydrochloride is a neuroprotective agent.
[Biological Activity]

Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na + and K + channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.
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