| Identification | Back Directory | [Name]
AMG2850 | [CAS]
1470018-52-0 | [Synonyms]
AMG2850
AMG 2850,Inhibitor,AMG2850,inhibit,AMG-2850,Transient receptor potential channels,TRP Channel
((R)-8-(4-(TRIFLUOROMETHYL)PHENYL)-N-((S)-1,1,1-TRIFLUOROPROPAN-2-YL)-5,6-DIHYDRO-1,7-NAPHTHYRIDINE-7(8H)-CARBOXAMIDE) | [Molecular Formula]
C19H17F6N3O | [MDL Number]
MFCD32067868 | [MOL File]
1470018-52-0.mol | [Molecular Weight]
417.35 |
| Chemical Properties | Back Directory | [Boiling point ]
452.7±45.0 °C(Predicted) | [density ]
1.354±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
11.53±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist[1].
TRPM8[1]. | [References]
[1]. Lehto SG, et al. AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia. Naunyn Schmiedebergs Arch Pharmacol. 2015 Apr;388(4):465-76. |
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