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ChemicalBook--->CAS DataBase List--->1448189-66-9

1448189-66-9

1448189-66-9 Structure

1448189-66-9 Structure
IdentificationBack Directory
[Name]

L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
[CAS]

1448189-66-9
[Synonyms]

JYS002
L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
[Molecular Formula]

C26H36N4O5S
[MOL File]

1448189-66-9.mol
[Molecular Weight]

516.65
Chemical PropertiesBack Directory
[Boiling point ]

754.7±60.0 °C(Predicted)
[density ]

1.235±0.06 g/cm3(Predicted)
[pka]

11.49±0.46(Predicted)
Hazard InformationBack Directory
[Uses]

VH032 analogue-2 is a VH032 (HY-120217) analog that acts as a ligand for VHL, recruiting von Hippel-Lindau (VHL) protein. VH032 analogue-2 will remove the protective group under acidic conditions, and can be directly used for the synthesis of PROTAC molecules. VH032 analogue-2 is a key intermediate for the synthesis of PROTACs based on VHL ligands.
[IC 50]

VHL
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