| Identification | Back Directory | [Name]
Thiol-PEG3-t-butyl ester | [CAS]
1446282-39-8 | [Synonyms]
HS-PEG3-COOtBu
Thiol-PEG3-Boc
SH-PEG3-CH2CH2COOtBu
Thiol-PEG3-t-butyl ester
Propanoic acid, 3-[2-[2-(2-mercaptoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C13H26O5S | [MDL Number]
MFCD25424074 | [MOL File]
1446282-39-8.mol | [Molecular Weight]
294.41 |
| Hazard Information | Back Directory | [Description]
Thiol-PEG3-t-butyl ester is a PEG linker containing a thiol group and a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Thiol-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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