| Identification | Back Directory | [Name]
4-([1,1'-biphenyl]-4-yl)-N-(6-methylpyridin-2-yl)thiazol-2-amine | [CAS]
1426047-44-0 | [Synonyms]
IND-24
4-([1,1'-biphenyl]-4-yl)-N-(6-methylpyridin-2-yl)thiazol-2-amine
2-Pyridinamine, N-(4-[1,1'-biphenyl]-4-yl-2-thiazolyl)-6-methyl- | [Molecular Formula]
C21H17N3S | [MDL Number]
MFCD28160621 | [MOL File]
1426047-44-0.mol | [Molecular Weight]
343.44 |
| Chemical Properties | Back Directory | [Boiling point ]
559.6±52.0 °C(Predicted) | [density ]
1.234±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.84±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
IND24 is a potent antiprion agent with an EC50 value of 1.27 μM. IND24 decreases abnormal, misfolded, pathogenic forms of benign normally occurring prion protein on the cell surface or inside the cell[1]. | [References]
[1] Silber BM, et al. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharm Res. 2013 Apr;30(4):932-50. DOI:10.1007/s11095-012-0912-4 |
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