| Identification | Back Directory | [Name]
WWL229 | [CAS]
1338575-28-2 | [Synonyms]
WWL229
Reaxys ID: 25732135
XVBRVSAGMWRVCK-UHFFFAOYSA-N
1-Piperidinecarboxylic acid, 2-(3-methoxypropyl)-, 4-nitrophenyl ester | [Molecular Formula]
C16H22N2O5 | [MDL Number]
MFCD28160858 | [MOL File]
1338575-28-2.mol | [Molecular Weight]
322.36 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | [form ]
oil | [color ]
colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
WWL229 is a selective inhibitor of Ces3 (carboxylesterase-3) which mediates triglyceride hydrolysis in white adipose tissue. Potential anti-diabetic agent. | [Biological Activity]
WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3)serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC50 of 10 μMbut not Ces1fABHD6 or other tested serine hydrolases. In a recent studyhCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjectsand is thought to generate surplus fatty acids th at can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes. |
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BOC Sciences
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