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ChemicalBook--->CAS DataBase List--->1331754-16-5

1331754-16-5

1331754-16-5 Structure

1331754-16-5 Structure
IdentificationBack Directory
[Name]

Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]-
[CAS]

1331754-16-5
[Synonyms]

Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]-
[Molecular Formula]

C6H8N2O2
[MDL Number]

MFCD28675904
[MOL File]

1331754-16-5.mol
[Molecular Weight]

140.14
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
[form ]

A crystalline solid
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1 It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50 = <0.01 μM), an effect that is reduced in the presence of vitamin B6 (EC50 = <100 μM).
[References]

1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016)
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