| Identification | Back Directory | [Name]
RO 41-0960 COMT IHIBITOR | [CAS]
125628-97-9 | [Synonyms]
or1139
Ro 41-0960 solid
Ro 410960,Ro 41 0960
RO 41-0960 COMT INHIBITOR
RO 41-0960 COMT IHIBITOR
(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-methanon
(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone
Methanone, (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)- | [Molecular Formula]
C13H8FNO5 | [MDL Number]
MFCD00078597 | [MOL File]
125628-97-9.mol | [Molecular Weight]
277.2 |
| Chemical Properties | Back Directory | [Melting point ]
169-171°C | [storage temp. ]
2-8°C | [solubility ]
H2O: <0.7 mg/mL, slightly soluble | [form ]
solid | [color ]
yellow | [Water Solubility ]
H2O: slightly soluble <0.7mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0mg/mL
ethanol: soluble |
| Hazard Information | Back Directory | [Uses]
Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to tre at corpus striatum samples to test its effect on dopamine metabolism. | [Preparation]
preparation by demethylation of 2′-fluoro-4- hydroxy-3-methoxy-5-nitrobenzophenone with 48% hydrobromic acid in refluxing acetic acid for 4 h (86%). | [Biological Activity]
Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids. | [storage]
Store at -20°C |
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Energy Chemical
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SIGMA-RBI
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