| Identification | Back Directory | [Name]
BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE | [CAS]
125-51-9 | [Synonyms]
qpb
jb-323
piptal
Piptalake
Pipenzolate
PIPENZOLATE BROMIDE
pipenzolatemethobromide
PIPENZOLATE BROMIDE(SH)
pipenzolatemethylbromide
XEDCWWFPZMHXCM-UHFFFAOYSA-M
PIPENZOLATEBROMIDE,ULTRAPURE
pipenzolate bromide sigmaultra
n-ethyl-3-piperidylbenzilatemethobromide
1-ethyl-3-piperidylbenzilatemethylbromide
benzilicacid,1-ethyl-3-piperidylestermethylbromide
3-benziloyloxy-1-ethyl-1-methylpiperidinium bromide
BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE
1-ethyl-3-hydroxy-1-methyl-piperidiniumbromidebenzilate
piperidinium,1-ethyl-3-hydroxy-1-methyl-,bromide,benzilate
benzilicacid,esterwith1-ethyl-3-hydroxy-1-methylpiperidiniumbromide
1-Ethyl-3-(2-hydroxy-2,2-diphenylacetoxy)-1-methyl-1-piperidinium Bromide
1-Ethyl-3-(2-hydroxy-2,2-diphenylacetoxy)-1-Methylpiperidin-1-iuM broMide
Pipenzolate BromideQ: What is
Pipenzolate Bromide Q: What is the CAS Number of
Pipenzolate Bromide Q: What is the storage condition of
Pipenzolate Bromide | [EINECS(EC#)]
204-741-2 | [Molecular Formula]
C22H28BrNO3 | [MDL Number]
MFCD00079275 | [MOL File]
125-51-9.mol | [Molecular Weight]
434.37 |
| Hazard Information | Back Directory | [Originator]
Piptal ,Merrell National ,US ,1955 | [Uses]
antispasmodic | [Uses]
Piptalake is used in the treatment with copper-tolylterpyridine and platinum-tolylterpyridine that targets telomeres and telomerase for regulation of chromosome mis-segregation rates for cancer therapy. | [Manufacturing Process]
N-ethyl-3-chloropiperidine was prepared according to the method of Fuson and Zirkle described in Volume 70, J. Am. Chem. Soc., p 2760. 12.0 g (0.081 mol) of N-ethyl-3-chloropiperidine was mixed with 18.6 g (0.081 mol) of benzilic acid and 80 cc of anhydrous isopropyl alcohol as a solvent. The mixture was refluxed for 72 hours. The solution was then filtered and concentrated at 30 mm of mercury. The concentrate was dissolved in water, acidified with hydrochloric acid and extracted with ether to remove theThe aqueous layer was neutralized with sodium bicarbonate and the product was extracted with ether. The ethereal solution of the product was dried with potassium carbonate, the ether was removed by distillation and the residue was distilled at 0.12 to 0.18 mm of mercury, the BP being 194° to 198°C. A yield of 16.5 g (60% of theoretical) of N-ethyl-3-piperidyl-benzilate was obtained.
34 g (0.1 mol) of the basic ester is dissolved in 75 cc of isopropyl alcohol and treated with 9.5 g (0.1 mol) of methyl bromide. The mixture is allowed to stand at room temperature until precipitation is complete. The product is removed by filtration and washed with isopropyl alcohol, yield 33 g, MP 175° to 177°C. On recrystallization from isopropyl alcohol, the MP was raised to 179° to 180°C dec. | [Brand name]
Piptal (Marion Merrell Dow). | [Therapeutic Function]
Spasmolytic |
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