| Identification | Back Directory | [Name]
TENIDAP | [CAS]
120210-48-2 | [Synonyms]
TENIDAP
AKOS 91367
TENIDAP USP/EP/BP
CP66248,CP-66248-2
5-Chloro-2，3-dihydro-2-oxo-3-(2-thenoyl)-1H-indole-1-carboxamide
(3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H-indole-1-carboxaMide
(Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H-
indole-1-carboxaMide
1H-Indole-1-carboxamide, 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, (3Z)- | [Molecular Formula]
C14H9ClN2O3S | [MDL Number]
MFCD00865996 | [MOL File]
120210-48-2.mol | [Molecular Weight]
320.75 |
| Chemical Properties | Back Directory | [Melting point ]
230° (dec) | [Boiling point ]
538.1±60.0 °C(Predicted) | [density ]
1.648±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: soluble1mg/mL, clear (warmed) | [form ]
powder | [pka]
4.50±1.00(Predicted) | [color ]
faint yellow to dark yellow |
| Hazard Information | Back Directory | [Uses]
Anti-inflammatory (osteoarthritis
and rheumatoid arthritis). | [Definition]
ChEBI: Tenidap is a member of indoles, a member of ureas, a member of thiophenes and an organochlorine compound. It has a role as a non-steroidal anti-inflammatory drug and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. | [Biological Activity]
NSAID that preferentially inhibits COX-1 (IC 50 values are < 0.03, 1.2 and > 30 μ M for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hK IR 2.3 channel (EC 50 = 402 nM). | [storage]
Store at -20°C | [Mode of action]
Tenidap is an anti-inflammatory agent developed by Pfizer with a unique structure that is different and distinguishable from NSAIDs. The mechanism of action of tenidap is that it has dual inhibitory effects on lipoxygenase and dioxygenase, and has antagonism on interleukin-1 (IL-1). |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|