| Identification | Back Directory | [Name]
Baclofen-d4 | [CAS]
1189938-30-4 | [Synonyms]
[2H4]-Baclofen
(±)-Baclofen-d4 (4-chlorophenyl-d4)
(+/-)-BACLOFEN (D4, 98%) 100 UG/ML IN METHANOL
Baclofen D4 HydrochlorideQ: What is
Baclofen D4 Hydrochloride Q: What is the CAS Number of
Baclofen D4 Hydrochloride Q: What is the storage condition of
Baclofen D4 Hydrochloride Q: What are the applications of
Baclofen D4 Hydrochloride | [Molecular Formula]
C10H8D4ClNO2 | [MOL File]
1189938-30-4.mol | [Molecular Weight]
217.685 |
| Hazard Information | Back Directory | [Uses]
Specific GABA-B receptor agonist. Muscle relaxant (skeletal). | [Biological Activity]
(±)-Baclofen-d4 is intended for use as an internal standard for the quantification of (±)-baclofen by GC- or LC-MS. (±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).1 It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.2 It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.3 (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.4,5 Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury. | [References]
1.Hill, D.R., and Bowery, N.G.3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brainNature290(5802)(1981)
2.Biscoe, T.J., and Fry, J.P.Some pharmacological studies on the spastic mouseBr. J. Pharmacol. 75(1)23-25(1982)
3.Sakitani, K.The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in ratsJpn. J. Pharmacol.63(3)369-376(1993)
4.Lhuillier, L., Mombereau, C., Cryan, J.F., et al.GABAB receptor-positive modulation decreases selective molecular and behavioral effects of cocaineNeuropsychopharmacology32(2)388-398(2007)
5.Moore, E.M., and Boehm, S.L., IISite-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J miceBehav. Neurosci.123(3)555-563(2009)
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