| Identification | Back Directory | [Name]
S-(2-thiopyridyl)mercaptopropionohydrazide | [CAS]
115616-51-8 | [Synonyms]
S-(2-thiopyridyl)mercaptopropionohydrazide
3-(2-Pyridyldithio)propionylhydrazide(PDPH) | [Molecular Formula]
C8H11N3OS2 | [MOL File]
115616-51-8.mol | [Molecular Weight]
229.32 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
87-90°C | [Boiling point ]
463.6±41.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
12.81±0.35(Predicted) | [color ]
White | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A fluorescent sulfhydryl active reagent | [General Description]
The PDPH is a heterobifunctional crosslinker containing sulfhydryl-reactive pyridyldithiol and carbonyl-reactive hydrazide moieties. Pyridyldithiols react with free sulfhydryls (-SH) to form disulfide bonds. Hydrazide groups react with carbonyls (aldehydes and ketones) to form stable hydrazone bonds. Aldehyde groups can be created by periodate-oxidation of sialic acid and other sugar components of glycoprotein polysaccharides. Thus, PDPH is useful for conjugating glycoproteins and sulfhydryl-containing peptides or proteins. Likewise, PDPH is useful as a sulfhydryl-addition reagent for glycoproteins and other carbohydrates; after reaction of the hydrazide to an oxidized carbohydrate, the pyridyldithiol group can be cleaved by a reducing agent to expose a sulfhydryl group. Yet another application for PDPH is to react the primary amine of the hydrazide moiety to a carboxyl group using the crosslinker EDC. | [reaction suitability]
reagent type: cross-linking reagent |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|