| Identification | Back Directory | [Name]
DIF-3 | [CAS]
113411-17-9 | [Synonyms]
DIF-3 >=99% (HPLC), solid
1-Hexanone, 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-
1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone, Differentiation-inducing factor 3 | [Molecular Formula]
C13H17ClO4 | [MDL Number]
MFCD05865230 | [MOL File]
113411-17-9.mol | [Molecular Weight]
272.72 |
| Chemical Properties | Back Directory | [Boiling point ]
416.9±45.0 °C(Predicted) | [density ]
1.240±0.06 g/cm3(Predicted) | [solubility ]
DMSO: 46 mg/mL, soluble | [form ]
solid | [pka]
5.92±0.45(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
DIF-3 has been used: as a glycogen synthase kinase-3β (GSK-3β) activator to determine if GSK-3β is required for the anti-inflammatory actions of VU0360172 (VuPAM) in murine microglia, as a phosphorylation inhibitor for GSK-3β to examine the links between activation of protein kinase B (PKB)/GSK-3β/Fyn axis and nuclear factor erythroid 2–related factor 2 (NRF2) retention, as a GSK3β activator to study its effects on the cyclooxygenase 2 (COX2) expression levels in human primary chondrocytes in response to visfatin, as a GSK3β activator to study its effects on the intracellular mechanics along with F-actin and β-tubulin fiber networks in human primary chondrocytes | [Biological Activity]
Differentiation-inducing factor-3 (DIF-3) prevents the proliferation of intestinal cancer cells in vitro and in vivo. It may serve as a novel anti-cancer agent.''DIF-3 Inhibits cell cycle by inducing G0/G1 arrest. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
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| Tel: |
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| Website: |
www.sangon.com |
| Company Name: |
SIGMA-RBI
|
| Tel: |
800 736 3690 (Orders) |
| Website: |
www.sigma-aldrich.com |
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