| Identification | Back Directory | [Name]
Cabotegravir (GSK744, GSK1265744) | [CAS]
1051375-10-0 | [Synonyms]
GSK744
CS-2197
GSK1265744
SureCN82803
S/GSK1265744
Cabotegravir
SK744, GSK1265744
Cyclic pyranopterin
Cabotegravir ,GSK744
GSK744 (S/GSK1265744)
Cabotegravir Free Acid
Cabotegravir (GSK-1265744）
Cabotegravir(GSK1265744A,GSK-744)
Cabotegravir (GSK744, GSK1265744)
Cabotegravir (GSK744, GSK1265744) USP/EP/BP
(3S,11AR)-N-(2,4-DIFLUOROBENZYL)-6-HYDROXY-3-METHYL-5,7-DIOXO-2,3,5,7,11,11A-HEXAHYDROOXAZOLO[3,2-A]PYRIDO[1,2-D]PYRAZINE-8-CARBOXAMIDE
(3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, (3S,11aR)- | [Molecular Formula]
C19H17F2N3O5 | [MDL Number]
MFCD25976748 | [MOL File]
1051375-10-0.mol | [Molecular Weight]
405.352 |
| Chemical Properties | Back Directory | [Boiling point ]
664.0±55.0 °C(Predicted) | [density ]
1.57±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in H2O; insoluble in EtOH; ≥19.35 mg/mL in DMSO with gentle warming | [form ]
solid | [pka]
4.50±1.00(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes. | [Definition]
ChEBI:Cabotegravir is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (3S,11aR)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1. It has a role as a HIV-1 integrase inhibitor. It is a difluorobenzene, a secondary carboxamide, a monocarboxylic acid amide and an organic heterotricyclic compound. It is a conjugate acid of a cabotegravir(1-). | [Biological Activity]
Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, inhibiting HIV-1 integrase-catalyzed strand transfer with IC50 of 3 nM. Phase 2. | [Mechanism of action]
Caboggravir is a potent inhibitor of HIV integrase, which prevents the HIV virus from infecting human cells, while rilpivirine prevents the virus from replicating itself. | [target]
HIV integrase | [storage]
Store at -20°C |
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