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ChemicalBook--->CAS DataBase List--->1041469-97-9

1041469-97-9

1041469-97-9 Structure

1041469-97-9 Structure
IdentificationBack Directory
[Name]

RKS-262
[CAS]

1041469-97-9
[Synonyms]

RKS-262
[Molecular Formula]

C15H14BrClN2O4S
[MOL File]

1041469-97-9.mol
[Molecular Weight]

433.7
Hazard InformationBack Directory
[Description]

RKS262 is a specific cycliCDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line assay RKS262 exhibited significant cytotoxicity in ovarian cancer cells and a variety of other cell lines exceeding effects of commercial drugs such as cisplatin, 5-FU, cyclophosphamide or sapacitabine. Various leukemia cell-lines were most sensitive (GI(50):?~?10 nM) while several non-small cell lung cancer cell lines and few cell lines from other tissues were relatively resistant (GI(50)?>?1?μM) to RKS262 treatment.
1041469-97-9 suppliers list
Company Name: TargetMol Chemicals Inc.
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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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