| Identification | Back Directory | [Name]
CINPA 1 | [CAS]
102636-74-8 | [Synonyms]
CINPA 1
Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate
Carbamic acid, [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester (9CI) | [Molecular Formula]
C23H29N3O3 | [MDL Number]
MFCD00288296 | [MOL File]
102636-74-8.mol | [Molecular Weight]
395.49 |
| Chemical Properties | Back Directory | [Boiling point ]
545.8±50.0 °C(Predicted) | [density ]
1.179±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: 100 mM; Ethanol: 100 mM | [form ]
A crystalline solid | [pka]
13.44±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CINPA 1 is an inhibitor of constitutive androstane receptor (CAR) which regulates the expression of genes involved in drug metabolism. | [Biological Activity]
CINPA1 is a ligand-binding domain (LBD)-targeting constitutive androstane receptor (CAR) inhibitor th at prevents CAR recruitment to promoter regions of regulated genes (by >85%; 1 μM CINPA1 against 0.1 μM CITCO-induced CAR recruitment to CYP2B6 or CYP3A4 promoters; human hepatocytes) by altering CAR-coregulator interactions. CINPA1 inhibits CAR-mediated transcription in a potent (IC50 = 70 nM; HepG2-hCAR1 CYP2B6-luc reporter cells) and selective manner with only weak PXR antagonist potency (68% inhibition by 18 μM CINPA1 against 5 μM rifampicin; HepG2-PXR reporter cells) and no cytotoxicity or agonist/antagonist activity toward FXRGRLXRα/βPPARγRXRα/βVDR. | [storage]
Store at -20°C |
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Syntechem Co.,Ltd.
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BOC Sciences
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https://www.bocsci.com |
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InvivoChem
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