| Identification | Back Directory | [Name]
CAY10704 | [CAS]
101784-44-5 | [Synonyms]
CAY10704
CAY10704,CAY-10704
Piperazine, 1-[bis(4-chlorophenyl)methyl]-4-methyl- | [Molecular Formula]
C18H20Cl2N2 | [MOL File]
101784-44-5.mol | [Molecular Weight]
335.27 |
| Hazard Information | Back Directory | [Description]
CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection (EC50 = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC50 = 21.3 μM).1 It displays good pharmacokinetics in mice when delivered intraperitoneally, with preferential liver distribution without significant hepatotoxicity.1 CAY10704 is selective for HCV over dengue virus (EC50 = 4.62 μM).1 | [References]
1. He, S., Xiao, J., Dulcey, A.E., et al. Discovery, optimization, and characterization of novel chlorcyclizine derivatives for the treatment of hepatitis C virus infection J. Med. Chem. 59(3),841-853(2016). |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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